Sánchez-Vargas LA, Mathew A
Future Virol 2019 Mar;14(3):161-169
PMID: 31073324
Abstract
Follicular helper T cells (T) are a predominant subset of CD4 T cells specialized in providing help to B cells in germinal centers and necessary to generate T cell-dependent antibody responses. Peripheral T (pT) are the counterpart of T found in the circulation, which resemble T in many aspects of their phenotype and function. The CD4 pT subset has received a lot of interest recently because they are easy to access and have the potential to serve as a biomarker for long-lasting humoral immunity. This review will discuss recent findings of pT in human acute viral diseases with a focus on dengue infection.